Saturday, August 31, 2019

Outline the Operations Processes Relevant to Transformations

Outline the operations processes relevant to transformations. Describe and explain the impact of the 4? s on the transformation processes. Operations refers to those ongoing cyclic activities involved in the running of a business for the purpose of producing value for the stakeholders. Operations includes the conversion of inputs (resources) into outputs (goods and services). This conversion is known as transformation. Thus, operations processes are those processes involved directly with transformation. †¢ Operations processes entails different processes relevant to transformations.Sequencing and Scheduling are two essential aspects that assist with structuring and ordering the transformation processes. Sequencing refers to the order in which activities in the operations process occur. Scheduling refers to the length of time activities take within the operations process. The two main scheduling tools are Gantt charts and Critical Path Analysis (CPA). An understanding of both seq uencing and scheduling is necessary for operations managers. †¢ As well as operations, technology is another aspect of the operations process which is relevant to transformations.Business technology involves the use of machinery and systems that enable businesses to undertake the transformation process more effectively and ef? ciently. Business technology may include a computer, keyboard and mouse, mobile telephones, printers etc. Manufacturing technology includes robotics, computer-aided designs (CAD) and computer-aided manufacturing (CAM). †¢ Task Design is relevant to transformations as it involves classifying job activities in ways that make it easy for an employee to successfully perform and complete a task. It overlaps the employment relations function of job analysis, job description and person speci? ation. †¢ A plant layout is the arrangement of equipment, machinery and staff within the facility (either a factory or of? ce). The plant layout have an impact on the ef? ciency of the operations function. Plant layouts ensure enough physical space for production, effective use of equipment, the use of appropriate technology, and a good work environment, to name a few. †¢ All operations processes should be monitored for their effectiveness. Monitoring is the process of measuring actual performance against planned performance. As well as monitoring, the main transformational process should be subject to control.Control occurs when KPIs are assessed against predetermined targets and corrective action is taken if required. This requires effective monitoring and focus on continuous improvement. Monitoring and control lead to improvements when there is a focus on quality and standards. Improvement refers to systematic reduction of inef? ciencies and wastage, poor work processes and the elimination of any bottlenecks. Monitoring, control and improv Transformation processes are in? uenced by volume, variety, variation and visibility. That is, the four V? – how much of a product is made, the range of products made, the amount of a product desired by consumers and the nature and amount of customer contact. The in? uence of volume has a strong impact on the transformation process. Volume refers to how much of a product is made. Volume ? exibility depends on the increase or decrease on the demand of a product. An example of a business which used volume as an in? uence for the transformation process is the manufacturers of Leapfrog Leapster Explorer. In 2010, the console became available for sale. However, there were more far more games than actual consoles.This meant that retailers had a shortage of consoles in comparison to games. This is a prime example of a situation caused by a supplier with an incorrect perception of volume. The in? uence of variety is the second ? V? that impacts strongly on the transformation process. Variety is the mix of products made, or services delivered through the transformation process. It is sometimes referred to as mix ? exibility. Mix ? exibility is known by customers as product range or variety of change. The in? uence of variety on transformation processes is the greater the variety made, the more the operations process needs to allow for variation.An example of a business that considers variety is Electrolux. Electrolux make Simpson, Chef, Dishlex and Westinghouse brands. These brands are attached to a range of whitegoods such as fridges, washing machines, ovens, dishwashers and dryers. In this way, the company can sell a variety of products made with largely similar production processes. A variation in demand can impact signi? cantly on transformation resources. Increases in demand will require increased inputs from suppliers, increased human resources, increased energy use and increased use of machinery and technology.The fourth and ? nal V that impacts the transformation process is the in? uence of visibility. Visibility is important in the transformation as it is the nature and amount of customer contact (feedback). Direct customer contact may include customer feedback given through surveys, interviews, letters, blogs and verbal contact. Indirect customer contact comes from a review of sales data that is an analysis of customer preferences. As businesses seek to maximize sales, customer contact is essential and ultimately shapes the transformation process.

Friday, August 30, 2019

Del monte VPN architecture suggestion for assignment

Del Monte Organization Structure Diagram. Source: Dolente. Co. Z The business halogens: Provide role-based access to network resources for employees and business partners Reduce administrative and network costs Provide high-confidentiality for business information on the network Network requirements: Flexible and adaptive security appliance provides a variety of secure remote access Pre-configured telethon solution provides convenient voice and data networking for home workers VPN solution integrates with existing network systems to enforce access policies Del Monte Diagram VPN protocols and technologies VPN generally can handle three of these scenarios such as Remote access network, ranch office connection network, also business partner/supplier network or can be called as Extranet. Some of the VPN technologies are MILS, Pipes and GREG. Pipes is an evolve form from the IPPP development and is shorted of being finalized by the IETF. It is an open architecture for IP packet encryption and authentication, thus it is located in the network layer. One of the VPN authentications that have been around for some time is Generic Routing Encapsulation (GREG). â€Å"It was first developed by Cisco as a mean to carry other routed protocols across a predominantly IP network.Some outwork administrators tried to reduce the administrative overhead in the core of their networks by removing all protocols except IP as a transport. † (Pearson, n. D. ) Multiprocessor Label Switching (MILS) is a standard-based technology used to speed up the delivery of network packets over multiple protocols such as ‘P, ATM and Frame Relay network protocols. It would allow us some significant improvements, not the least of which was an increase in speed. Perhaps the most important to us at the time, though, was that each branch could directly connect to both WHQL locations without the need for an additional PVC. It also allows every branch to communicate directly with every other branc h without traversing the WHQL locations.This is important as if we were looking to implement a Poi solution. VPN service provider must have a network infrastructure that can support of integrating remote access directly into an MILS VPN network in order for it to provide a good scalable and complete end-to-end VPN service. The customers can be Sips or large enterprises that want to provide access to remote users but avoid the need for maintaining their own separate and expensive access network. Virtual Private Network (VPN) uses hared public telecoms infrastructure, such as the internet, to provide secure access to remote offices and users in a cheaper way than an owned or leased line.VPN are secure because they use tunneling protocols and procedures such as Layer 2 Tunneling Protocol (LOTT) and Point-to-Point Tunneling Protocol (PPTP). For this case in this assignment, I would suggest Pipes as the VPN technologies and authentication. This is the same as a basic concept that is bein g introduced by Security Association. The Job of AS is to make sure two or more entities secure when they are communicating with each other. Pipes itself has many options in providing security which includes encryption, integrity, and authenticity. For determining the Pipes security in details, both of Pipes peers must determine exactly which algorithm to use (e. : DES or DES for encryption, MAD or SHAH for integrity). Then continue with exchanging and sharing session keys. â€Å"An Pipes transform in Cisco ISO specifies either an AH or an ESP. protocol and its corresponding algorithms and mode. The Cisco Secure VPN Client uses the concept of security policies to specify the same parameters. † (Cisco Press, n. D. ) Network Solutions for Del Monte Major and required equipment and their significance Some important equipment that needed by the office are: Cisco AS 5500 series Adaptive Security Appliance Cisco MAC Appliance The Cisco MAC Appliance is a turnkey solution that conde nses the four MAC functions into one appliance.Some of MAC components are: Cisco NAS, Cisco NAME, Cisco ANA and Rule-set updates. MAC helps maintain network stability by providing authentication and authorization, posture assessment, quarantining of noncompliance systems and remediation of noncompliance systems. Cisco Secure ACS Cisco AS 5500 Series Adaptive Security Appliance is the best suit for Del Monte. This series provide advance firewall, compatible with the VPN architecture, Intrusion Prevention and content security all in single platform. It is also an industry-leading secure mobility technology for an organization. With its Suspect VPN edition, Del Monte offers employees a wide range of remote access options.An offside worker can set up a clientà ¨les VPN connection using a web browser without pre-installed software. And also, SSL technology that delivers secured access to network by establishing an encrypted tunnel across the internet. Some of the specific details of Cis co AS sass's features: Cisco Easy VPN This feature centralized the management of VPN deployments and helps reduce their complexity. Centralized the management is done by managing Pipes policies and push to the client device by the server. It also allows a remote end user to communicate using IP security with any Cisco ISO VPN gateway. VPN authentication The authentication is done with Cisco Secure Access Control Server (ACS).ACS is an access policy control platform that helps you comply with growing regulatory and corporate requirements. It is utilized for wireless infrastructure. This ACS helps improve productivity and contain costs. ACS works with VPN and other remote outwork access devices to enforce access policies. It also supports administrators' authentications, authorizes commands and provides an audit trail. Cisco Anecdote VPN Client LANA-like users can use it for the network connection optimization in a full tunnel client mode on a variety of end-user platforms. Customizab le SSL VPN and Pipes Services for Any Deployment Scenario Depending on the series of the AS 5500, PIPS SSP is built-in to help preventing the intrusion.The Cisco AS 5500 Series helps businesses increase effectiveness and efficiency in protecting their networks and applications while delivering exceptional investment retention through the Market-proven security capabilities, Extensible integrated service architecture, Reduced-deployment and operations costs also Comprehensive management interface. Company's ERP and CRM Cisco VPN actually integrates smoothly with Del Mote's existing network to give employees access only to the resources that they need. This meaner that VPN will make sure only the authorizes users can access to the certain parts of the network and company resources. ERP integrates all departments and functions throughout an organization into a single IT system so that employees can make enterprise-wide sessions by viewing enterprise-wide information on all business ope rations.Enterprise System Automate business process ERP systems collect data from across an organization and correlate the data generating an enterprise-wide view to help run the business. Measuring ERP success There are several different departments in the company. Example, sales representative might need to access to Del Mote's data warehouse system (CRM) application to track a shipment. While finance organization need to access to ERP system, file sharing and administrative tools from their portal. So Cisco VPN makes ere that each department can only access to their own but not others. And yet IT professional might need access to everything on the network for troubleshooting or monitoring.Security To provide additional network security for remote employees, Del Monte can use the Cisco MAC appliance to enforce security policy compliance. It identifies the security policies before permitting those devices access to the network. Cisco MAC appliance is a network admission control tha t is designed by Cisco to produce a secure and clean network environment. Two Pipes Peers Using Active Directory-based Pipes Policy, Source: techno. Microsoft. Mom Pipes packet filtering Pipes has an ability to provide limited firewall capabilities for end systems by performing host-based packet filtering. It also can be configured to permit or block specific types of incase IP traffic based on source and destination address combinations and specific protocols and specific ports.While the security can be strengthen by using Pipes packet filtering to control exactly the type of communication that is allowed between systems. Filtering Packets by Using Pipes, Source: techno. Microsoft. Com Types of attacks Some of the possible attacks that can happen to VPN are: Brute force attacks and cautionary attacks. STEP attacks An STEP attack typically involves the creation of bogus root bridge. This can be accomplished using available software from the internet such as broccoli or step- packet. In this attack, Buds sent by the attacking host announce a lower bridge priority in an attempt to be elected as the root bridge, then the topology change Buds to force spanning-tree recalculations.If successful, the attacking host becomes the root bridge and sees a variety of frames that otherwise are not accessible. STEP attacks Brute force attack A cryptanalytic type of attack that is used against any encrypted data to guess the seer's surname and password. It is simply because this attack has a dictionary of commonly used passwords and cycle through those words until it gains access to the account. Brute force attack takes different variety times to complete as it is depending on the number of encryption size (64-bit, 128-bit or 256-bit). The higher number of the encryption, the longer time it is needed by Brute force to accomplish its attack.Dictionary attack A technique which is used by hacker to determine the decryption key of the authentication mechanism by trying it repeate dly until the real possibility is come UT. Basically, it is acting like a person who searches a keyword from a dictionary. Yet this attack only tries the best possibilities that are most likely to success. References: J. Charged and J. Pacer, MILS and VPN Architectures, 1st deed. Indianapolis, IN: Cisco System, Inc. , 2003. G. A. Donahue, Network Warrior, 2nd deed. Soapstone, CA: Reilly Media, 2011. J. Afraid and O. Santos, Cisco AS, 2nd deed. Indianapolis, IN: Cisco System, Inc. , 2010. O. Santos, End-to-end network security, USA-landslips, IN: Cisco System, Inc. , 2008. Pipes security. Retrieved from http://techno. Microsoft. Com

Thursday, August 29, 2019

Edward Albee’s presentation of Nick and his role in Who’s Afraid of Virginia Woolf

In ‘Who’s afraid of Virginia Woolf’ by Edward Albee, a main character that is revealed in this play is Nick who plays an important role presented by Albee in different ways. The play which, ‘’shows malicious humiliation and love and tenderness and bitterness’’ is set on the campus of a small, New England university. Nick is presented in part as an on-stage audience for George and Martha to act out their verbal banter. Moreover the character of nick is used as a compare and contrast to George. The audience sees nick as an image of youthful pride, unblemished, athletic whose very life is dedicated to eliminating the imperfections in human genes, but is himself revealed as flawed in the play. The young couple Nick and Honey are presented as ‘’passive observers. They serve solely as the objects of manipulation’’. George and Martha simply use the younger, less experienced couple to manoeuvre for advantage in their own bitter struggle. This is further shown in act two by George when he states, ‘’I’ll tell you what game we’ll play. We’re done with humiliate the hosts†¦ how about a little game of get the guests?† George attempts to regain power which is an ongoing theme in the play by humiliating nick and honey. He uses what nick told him about honey’s hysterical pregnancy against them.Could Cold War Have Been Avoided? Secondly, Nick’s role as a compare and contrast to George is important as both of them possess certain traits that the other lacks and envies. While George is frustrated with his life and the illusions that Martha and he have made, Nick contrastingly is yet to rise in his conquest for power. Throughout the entire play, George and nick proceed through an ongoing verbal battle, competing for the position of high standing power. George attacks nick’s profession because he is afraid of artificially changing the way that people are supposed to turn out, ‘’ I've been drawing you out on this stuff, not because I'm interested in your terrible lifehood, but only because you represent a direct and pertinent threat to my lifehoood George openly admits that he's intimidated by Nick's youthful potential, and that he's seeking a way to undermine it. The audience see’s nick as an ideal man, coldly ambitious, good-looking and athletic who represents the idea of technological advancement. According to Martha he depicts, ‘’the perfect paragon of beauty and achievement’’. But as George and Martha ruthlessly involve them in their verbal battles, Albee reveals many flaws in nick in particular. It becomes revealed that the marriage of Nick and Honey is less than perfect and has serious problems. The appearance of a perfect marriage between Nick and Honey is shattered by Nick's admission that they got married because she was pregnant as stated by Nick, ‘’ I married her because she was pregnant. [†¦] It was a hysterical pregnancy. She blew up, and then she went down’’. Additionally Nick, the perfect model of a new faculty member, is rather easily seduced by Martha, â€Å"That’s right, lunkhead; answer the door†¦or are you too drunk to do that, too? Can’t get the latch up, either? Since nick failed to perform in the bedroom, he has lost all status in his relationship with Martha. This also makes one doubt the love in his marriage to honey. In who’s afraid of Virginia Woolf by Edward Albee, nick is a very important character presented by Albee. Not only is he presented in part as an on-stage audience for George and Martha, he also exposes the falseness of â€Å"The American Dream’’ through his relationship with honey. As the perfect image of Nick and Honey crumbles, the final idealization of marriage and family also collapses. Edward Albee suggests that people in America are living in an illusion to which they hold on dearly to avoid facing the reality of a perfect marriage, children, wealth, success, education and religion, All of which compromise the American dream and hence Albee attacks and mocks this idea in the play which is revealed by the main characters to the audience.

Resume and cover letter Essay Example | Topics and Well Written Essays - 500 words

Resume and cover letter - Essay Example This has made me more capable in handling certain circumstances under extreme pressure. I do realize that many jobs in the business world require a person to have a strong and stable character which can handle a stressful environment. I can do this. I have been attempting to bring improvements into my life since reaching the United States 10 years ago and my educational progress has only been one of the areas that I have found to bring remarkable attributes for myself. Due to the fact that my sister is already an employee of your company I have learned a great deal about the skills that would be required for the position of a ‘program specialist’ with the business. I am aware that I would need to have dedication and a good deal of knowledge in online marketing and with advertising programs as well. My educational training has earned me a degree that covers these various areas so I feel totally confident that I would be an asset to your company, which is my main goal. I also am aware that excellent verbal and other communication skills are a must in order to work for the company and I am proud to say that I have developed my English skills most proficiently and could be viewed almost as a native speaker. Also, I do believe I have a great personality and am easy going, and very willing to work along side others in a collaborative type of environment to achieve the company’s goal. Most importantly for myself, I want to be employed with a company that has longevity and values its employees, which I am certain that your business can do as I have heard nothing but positive remarks about the company. In order to give a better view of my skills and past experiences through the education and employment that I have acquired my resume is attached. I look forward to hearing from your company and am hoping for a

Wednesday, August 28, 2019

Refusal letter Essay Example | Topics and Well Written Essays - 250 words

Refusal letter - Essay Example One of our legal policies is to present terms and conditions of service to our clients before we enter into contract with them and we allow the client to review condition of the available facilities. Our contracts are therefore based on clients’ satisfaction with the state of our facilities before they make an offer for our services. This is based on the legal maxim that advertisement is an invitation to treat and not an offer (Mann and Roberts 173). Consequently, we assume that you placed an offer for our services based on your assessment of the state of the facilities and accepting your offer established the contract. It would therefore be unfair to shift blame on us for your failure to establish the level of utility that you could derive from our facility. Accepting your offer to use our facility entitled us to the payments and a refund would not be possible. You should have also noted in the contract that our policies do not provide for refund on received services. We would be happy to take every necessary measure to ensure that your next stay in our hotel derives the highest level of utility to you. We will also forward your concern to our legal expert who will inform you of the extent to which we met our obligations, based on the contract that you signed with us. We look forward to a long-term relationship with

Tuesday, August 27, 2019

Aliens exist Research Paper Example | Topics and Well Written Essays - 1500 words

Aliens exist - Research Paper Example Hence the survival of the fittest phenomena led to the birth of human beings who are supposed to be the perfect specie on the face of this earth. Human beings also known as Homo sapiens created civilizations which are still known to the whole world. As time passed by it was discovered that the planet in which we live is known as the earth and there is a whole galaxy outside. Gradually it also became known that other planets existed in this world. Now the question arose in the mind of human beings that if other planets could exist in the galaxy then it was also quite possible that other forms of life also existed besides the Homo sapiens. Other forms of life on planets other than Earth were given the name of aliens. However it is yet to be proved that aliens do really exist or not. On this issue there has been a large debate going on in this world and several organizations have been formed to report any unusual activity which might be performed by powers outside this world. This argum entative essay would present the arguments from both sides regarding the existence of aliens and would provide a conclusion which would judge as to if the aliens do really exist or not (Caldwell 2005; Murray 2009; Brockwell 2008). It has been reported that many unusual activities have taken place in this world which might be influenced by power residing outside this world. Many individuals have faced these unusual activities and report these activities to the relevant organizations. Some individuals put forward the claim that they have been abducted by the aliens while some put forward the claim that they had sighted a UFO near their house. However these findings have yet not provided a solid proof regarding the existence of the aliens. Brockwell on this issue provides with rather interesting information regarding the existence of aliens. According to Brockwell in 1966 a space shuttle was sent to generate electricity by the earth’s magnetic field. This

Monday, August 26, 2019

Social and cultural diversity in united arab emirates Research Paper

Social and cultural diversity in united arab emirates - Research Paper Example These factors affect relations that people have and what they do in various important situations and one of the most notable influences that they have is the influence on the media. Some of the factors that affect communication in UAE include; religion, sex and dress code for different people in the environment. These factors are not a reserve for anyone but they affect all people, whether they are locals or foreigners who stay in the UAE (King, 2008). Religion is one of the factors that affect the way people of the UAE differ or identify themselves from other places of the world, who do not come from the country. For example, in Dubai, there are numerous mosques where people convene for prayers and they are uniquely identifiable from different points. This has influenced the culture of the people who stay in that place at any time of the year regardless of the different backgrounds they could have in terms of religion in that they have to respond to different calls for prayer in cer tain ways. For example, the religious culture of the people of the UAE does not allow any person to eat in public daylight in the month of Ramadhan regardless of the differences in the religious beliefs (Terterov & Shoult, 2006). On the other hand, people in the UAE have particular dress codes, which is unique in different contexts and all the people ought to conform to requirements in such contexts. For example, while people can be on swimwear while they are around the beach, in conservative areas in Dubai, they should wear modestly in conformity to the requirements of the culture. People should not wear shorts and T-shirts when they enter the mosques for any activity, although they are not restricted to wear them when they are in town (Terterov & Shoult, 2006). Differences in sexes are identifiable when it comes to the people in the UAE because they should show different behavior in their various activities in the course of life. In UAE, women should cover their heads when they go to the mosque but men can go without covering their heads and do any activities in there. The roles vary in terms sexes in UAE with men acceptably allowed to conduct services in the mosque but women should not (Terterov & Shoult, 2006). In the UAE, there factors of that serve as the identity for the people and that are important aspects of media because they have a great influence in the lives of people. This is because what the culture allows publication is what the media of communication should transmit to the people according to cultural sanctions of the UAE. The issues, which are not favorable to the dominant Muslim culture in UAE, are not likely to go on air because it has a strict disciplinary action for the people who deviate. This means that the media in UAE is under the obligation to fulfill the cultural expectations as set out in the traditions of the place in which they are working. Media in UAE has to formulate policies in their services delivery that represent the cult ure of people in the country so that they will not deviate from the right purposes (Ward, 2013). Media is influenced by differences in the people who stay in the area because they have limitations in terms of the different things that they can display in the videos or papers. In the representation of videos and other forms of information, the coverage of things that pose social conflicts is regulated majorly by the popularity of the

Sunday, August 25, 2019

Islamic exam Essay Example | Topics and Well Written Essays - 1500 words

Islamic exam - Essay Example His arguments were clear and simple, he stated that two major sources of sharia, the Quran and Sunnah did not demand or altogether reject the caliphate, secondly there was no ijma done by the scholars upon the necessity of keeping caliphate, thirdly, caliphate had only brought disasters in the Muslim world and there were no logical arguments to re-establish it. The book also criticized rulers who used the Islamic laws in order to form a political guideline and rules for the ruling authorities. Furthermore, the book stated that the role of Prophet Muhammad was solely as religious spiritual teacher and nothing near to as a political leader. These statements called on for huge debates and unrest between different groups of Islamic world. Al-Raziq has been declared as the father of secularism of the state and not only the society, in Islamic governance. Secularism separates a state from all religious linkages and allows people from different religions to be treated equally by law regardless of religion by the ruling authority or the majority of the country’s population. Al-Raziq never called keeping an Islamic government unlawful; he furthermore declared that Muslims altogether may agree to any form of government they want to keep as long it kept the common interest of the society they are ruling in their mind. This shows that altogether, al-Raziq had a very humanistic approach towards formation of government and supported democracy. Ruhollah Moosavi Khomeini was born in the early 1900’s and is famous for founding the first ever Islamic government called Islamic Republic or Iran. He was a politician and a revolutionary, the brains behind the Iranian Revolution that took place in 1979. After the Shah of Iran was overthrown, Khomeini became the sole ruler of the country and created a constitution solely on the bases of Islam and its

Saturday, August 24, 2019

Marketing - The movie ' Valentines Day ' Term Paper

Marketing - The movie ' Valentines Day ' - Term Paper Example It is the sheer ingenuity of these marketing and promotional campaigns that sell the movies regardless of how critics evaluate them. This is best accentuated by the example of the release and eventual success of the movie ‘Valentine’s Day’ which immediately stormed up to the top of the charts and made millions of dollars despite the fact that the movie failed to offer a plot that was anything beyond appalling and was popularly disparaged by critics. Not only the gist is vague, the movie has also been criticized for being loaded with offensive, controversial and questionable content (Goodwyn). However, it managed to achieve the number one rating when it opened and caused quite a stir in the box office. The movie was marketed with the obvious yet the most selling strategy of being tied with a major and popular holiday. To title the film after Valentine’s Day is a very calculated effort to capitalize on the emotions that are elicited around this holiday and at the same time to target an audience for whom the movie becomes a prime attraction on this very particular day just because of its name as it is a perfect present as well as a ‘going-out’ event. Lucy Fisher captures this is a very sleek manner when she comments that "People are prodded to buy something for the occasion, and in this case, its a movie ticket.. it doesnt matter about the quality† (Hare, 2010). Not only that, it a clever ploy to target women who are lured into the trap of saccharine love stories, cute stuff toys, red roses and the fever of the holiday. It is in this way that the movie self-advertises itself by its name enough to drive hundreds and hundreds of love-struck couples of all age s, young group of friends or even those lonely ones who need an exciting event towards the path that leads to the theaters. Even if the movie is perceived to be of poor

Friday, August 23, 2019

Factor behind the fall of communism in Eastern Europe Essay

Factor behind the fall of communism in Eastern Europe - Essay Example Communisms can also be well-defined as the principle of the circumstances of the public or waged people. This is a category of people in the society who live totally from the sale of their labour without profit and capital gains.   The proletariat in a word is the working class of the 19th  century. The lay man’s understanding of communism is that it is the rule of the gun in which the elite minority control the masses through all manner of oppression and exploitation, it started in 1945 and ended in 1991. Before the end of cold war in 1991 the world was divided into two blocs the Eastern and the Western (Western Europe and America). The Eastern Bloc which was the communist comprised of the Soviet Union, Poland, Czechoslovakia, Romania, East Germany, Hungry and Yugoslavia, with Poland being the largest communist country  apart from the Soviet Union however there were other communist  countries outside Europe such as Cuba (Levesque, 2010, p. 7). Many factors were respon sible for the collapse of communism, in this essay only three are explored namely nationalism, economic and ideology. Great emphasis is placed on economic as the main cause that affected Eastern Europe. Communism collapsed in 1989 and the iron curtain was dismantled with the demolition of the Berlin wall (Zubok, 2010, p.7). A long period of silence existed known as the cold war and set the world in two separate blocs the western and the eastern plus their allies. The standoff resulted into tension, suspicion, anxiety and fear among the rivaling blocs. An opaque situation existed known as the Iron Curtains that promoted heinous acts of oppression, nepotism, corruption and lack of accountability between the two blocs. This resulted into separation of Europe with a manmade Berlin wall. The insecurity and tension felt on both sides led to the nuclear arms race giving rise to the development of defense organizations in Europe i.e. the WARSAW pact and the NETO (Howard, 2003, p. 10). Befor e looking at the factors that led to the overthrow of communism

Thursday, August 22, 2019

The issue on war Essay Example for Free

The issue on war Essay The issue on war in our society today is sure to stir a hot debate. Much more among Christian circles. After 9/11 and the continuing war in Iraq, Americans and the world in general, had become divided along sharp lines. Most conservatives are more likely to support war while the liberals are more likely to oppose. It is quite interesting that wide support comes from the Evangelical Christians. A 2002 survey showed that Evangelicals were found to be the most supportive sector of the population who are in favor for the war in Iraq. Not a few were perplexed: isn’t this a contradiction to Biblical teachings? Is it not, that Christians were taught by Jesus to be â€Å"peacemaker† (Matthew 5:9)? Isn’t the God that they worship described as the â€Å"Prince of Peace† in the book of Isaiah (Isaiah9:6)? Does the Church go for war, with the belief that through this means it will triumph in love? Aren’t they instead, taught to love in order to prevent war? In both sides of this issue, we will find men and women who are truly sincere and honest upon their convictions. In fact, Scriptural tests can be found to support both â€Å"pro-war† and â€Å"anti-war† positions. Inherent upon these questions are also directed on whether God is either for or against war. The Old Testament is filled with battles and even indicates God directing or going out to battle with His people (as long as it is sanctioned by Him). On the other hand, the New Testament teachings seemed to contradict or oppose the ways written in the Old Testament. It is filled with teachings and different expressions of love for God, towards one’s neighbors and even to the point of loving one’s enemies. Does God’s Word run contradictory by itself; does God contradict Himself? Consequently, do Christians, as followers of Christ, express love at all times and never resort to the use of sword? Would this principle apply at all times, as exemplified by Jesus and the Christian martyrs who gave their lives to the point of death? Or should they follow Old Testament examples of going to war in order for peace and love to reign? This study attempts to answer how Christians can rejoice in serving a God of love, who is also a God of war. Also, this paper will try to demonstrate how the same power that lifted up and brought unspeakable joy to the saints of God, is the same power that worked through God’s mighty men, as they fought through battles and received victory, for as long as they lived in obedience to His instructions. II. The Nature/ Character of God It is important, that before we attempt to answer the questions mentioned above, one must lay first the proper foundation from which we will build our understanding of this particular issue. Before attempting to answer what God is for, we will first attempt to know what he is like. For much of what he does or does not do stems from who He is, and His character. He will never do anything that is out of His nature and character. Theologians have tried to describe God in various, different ways. He is known as the all-knowing, all-wise, all-powerful God. He is the source of substance from which all human virtues flow. He is the God who is able to do anything and everything; the one who possess everything GOOD that we would like to be. He is the only one who is omnipotent (all-powerful); omniscient (all-knowing); or omnipresent (present everywhere). God is a Spirit, who is eternal and ever living; the one, who has no beginning or end. He is a Person, referring upon Himself as â€Å"I am†, or the â€Å"Great I am†. In His person is the essence of love and He reveals Himself as a loving, merciful God. He is also holy meaning high above or cut above, and part of His holiness is His being righteous. No evil or wrong can be found in Him. Therefore, He alone is the righteous judge totally fair and just. The God that we speak of is no other than the Creator God. His power is what sustains the universe, existing outside creation. He is also present in it, which theologians call ‘immanent’, in which He sits as ruler over-all. Though He exists in nature, He is not nature, nor is He bound by the laws of nature. The best description of God was given by God Himself, through the name which He revealed of Himself to the Israelites, the name Yahweh. It is usually translated as â€Å"Jehovah† or â€Å"Lord†. The name is the hiphil tense of the Hebrew verb â€Å"to be†, which suggest to mean â€Å"He who causes (everything else) to be† (P. Robertson. Answers to 200 of Life’s Most Probing Questions). To know the name of God is to know His character. The names of God, found in the Bible, are God’s way of revealing Himself His nature and character. At the heart of everything that God is and does, lies in the essence of His very being that He is love. Love defines His character, and the reason for all His actions: â€Å"†¦. God is love† (I John 4:8b). God is eternally one, of a single mind and purpose, and unchanging. If God is love, he is love before the creation of the world until after the end of time. He was, is, and will always be. He never changes. His love is not dependent on our actions God is not love if I obey Him; vengeful if I disobey. All of His actions and purposes are consistent with love. Although much of the Old Testament records a lot of battles and wars, either with God directing the Israelites to fight or, the battles are directed against them with God’s sanction, this does not go against His loving character. Whichever, still God revealed Himself to Israel as one who loves and keeps His covenant of love-relationship with them (Deuteronomy 7:6-13a). III. The Kingdom of God Second foundation is, to acknowledge and to understand the existence of two spiritual kingdoms. A kingdom is a place where a king rules. For God’s kingdom, wherever God reigns, there His kingdom exists. The kingdom of God is not visible, nor determined by spatial boundaries. It is a spiritual kingdom, therefore not visible in the naked eye. Jesus Christ said, â€Å"The kingdom of God is within you† (Luke 17:21). Jesus gave his followers a pattern of prayer, commonly referred to as the Lord’s Prayer and in it a petition to God which says: â€Å"Your kingdom come. Your will be done on earth as it is in heaven† (Matthew 6:10). Jesus showed through this prayer, His priority of God’s kingdom. In the kingdom of God, everything is subject to God’s power, with no question. The kingdom of God is eternal. For now, it exists as an invisible kingdom here in our midst. Wherever there are those who honor Jesus Christ as the King and Lord over all, and wherever the Spirit of the King is, there is the kingdom of God. However, in the visible world, there is resistance to God’s will. This resistance is influenced by another kingdom, ruled by Satan. This kingdom led by Satan and his cohorts, is warring against God, His holy angels and his followers. It is also invisible to the naked eye. These two invisible kingdoms influence the visible world. Though the war has been won by Jesus on the Cross and his ascension to the right hand of God, the battle is still raging for the souls of men. IV. The Impact of the fall of Man The battle for man’s soul began with the first man, Adam. With Adam’s disobedience to the terms of his rule, man â€Å"falls† thereby experiencing the loss of his â€Å"dominion†. As man’s relationship with God is severed, who is the fountainhead of his power to rule, everything of his delegated realm (Earth) comes under a curse. Man loses the â€Å"life† power essential to ruling in God’s Kingdom. Moreover, through his disobedience to God and submission to the Serpent’s suggestions, man’s rule has been forfeited to the Serpent. In Revelations 12:9, it verifies that the spirit using the snake’s form was Satan himself. The domain originally delegated to man now has fallen to Satan (the prince of this world), who becomes administrator of this cursed realm. The Serpent’s â€Å"seed† and â€Å"head† show a continual line of evil offspring who carry out Satan’s rule. However, amidst the tragedy and bleak picture, God offers a way out. God, in his great love for man (despite their rebellion against Him), has moved His plan of redemption, and a plan to restore man’s lost estate through Christ Jesus, His only begotten Son. Thus, the battle for the soul of man, and man battling within himself (against his sinful nature), is real. V. Covenant Relationship A beautiful picture of God’s plan of redemption for all mankind is seen in His relationship with Israel. Salvation is for all, but God planted the ‘seed’ of salvation through the nation of Israel, choosing them as a holy people, separated for His plan and purpose. Through the Israelites, God battles to restore the mankind back to Himself, and save them from eternal punishment. VI. Conclusion A. The Victory of Christians As a conclusion, Every Christian should have spiritual victory. Robert Laurin, in Baker’s Dictionary of Theology, says: â€Å"Victory is above all a religiously conditioned concept in Scripture. This is rooted in the basic biblical principle that God is just, punishing sin and rewarding righteousness Victory is for the vindication of God’s purposes, or because of righteous living on the part of God’s people†¦ â€Å"In the OT victory is almost exclusively over external foes and issues in physical peace and security. But in the New Testament victory is expressed mainly in terms of spiritual forces and blessings. It is not triumph over social or economic difficulties that are the concern of the NT; it is mastery over temptation and the powers of evil†¦ â€Å"Thus victory is both present and eschatological. It is now that a Christian enters into the power and blessings of a triumph yet to find its complete realization in the future. † (See â€Å"Victory†). For all believers in Christ, the unseen world is not a fictional cosmos but a reality that had, and still continuous to have implication for all. Satan’s kingdom has waged war against the Creator God and his people, since the time of Adam, and has sought to bring defeat and disgrace to both. Martin Luther’s hymn, A Mighty Fortress Is Our God, says: â€Å"With cruel and dreadful might, he arms himself to fight; on earth he has no equal†. References: Robertson, P. Answers to 200 of Life’s Most Probing Questions. 1984 Johnson, IB. â€Å"God is Love†. 3rd chapter on Systematic Theology. â€Å"Truth†. http://www. inspiredbooks. com/Truth. htm â€Å"Victory†. Cited in Adult Teacher Supplement. 1969 Martin, M. â€Å"Spiritual Warfare: Biblical Armament for Victory†. http://www. answers. org/issues/spiritual_warfare. html Spirit Filled Life Bible. New King James Version. 1991

Wednesday, August 21, 2019

Rmsa Essay Example for Free

Rmsa Essay With the liberalization and globalization of the Indian economy, the rapid changes witnessed in scientific and technological world and the general need to improve the quality of life and to reduce poverty, it is essential that school leavers acquire a higher level of knowledge and skills than what they are provided in the 8 years of elementary education, particularly when the average earning of a secondary school certificate holder is significantly higher than that of a person who has studied only up to class VIII. It is also necessary that besides general education up to secondary level, opportunities for improvement of vocational knowledge and skill should be provided at the higher secondary level to enable some students to be employable. 1. 1. 4. Since universalisation of elementary education has become a Constitutional mandate, it is absolutely essential to push this vision forward to move towards Universalisation of secondary education, which has already been achieved in a large number of developed countries and several developing countries. Paras 5. 13 – 5. 15 of the National Policy on Education NPE), 1986 (as modified in 1992) deal with Secondary Education. Para 5. 13 of the NPE, inter- alia, stated that â€Å"Access to Secondary Education will be widened with emphasis on enrolment of girls, SCs and STs, particularly in science, commerce and vocational streams†¦Ã¢â‚¬ ¦. Vocationalization through specialized institutions or through the re-fashioning of secondary education wil l, at this stage, provide valuable manpower for economic growth†. Page 1 of 65 1. 1. 5. Hon’ble Prime Minister in his Independence Day Speech, 2007 has inter-alia stated that, â€Å"We are setting out a goal of universalizing secondary education. This is clearly the nest step after universalizing elementary education. While the goal is laudable much work needs to be done before we are in a position to launch the Scheme for Universalisation of Access for Secondary Education (SUCCESS). Its details need to be quickly spelt out and discussed with States so that we are fully ready to launch it from 2008-09. We must not underestimate the complexity of this task as the principles for universalizing elementary education cannot be easily transferred to secondary education. The physical, financial, pedagogical and human resource needs are quite different. We also need to recognize the role currently being played by the private sector and policy design must factor this in. Detailed strategies and plans would need to be worked out rapidly for each state. Special attention would need to be paid to Districts with SC/ST/OBC/Minority concentrati

Types of Tissue and Muscle

Types of Tissue and Muscle Muscle Muscle is one of the four fundamental types of tissue present in animals. It is a soft tissue primarily responsible to produce movement of a body part. Its cells convert the chemical energy of ATP into the mechanical energy of motion and exert a useful pull on another tissue. More specifically, muscle contraction serves the following overlapping functions: movement and contractile move of body contents in the course of respiration, circulation, digestion, defecation, urination, and childbirth. Stability by resisting the pull of gravity. Communication. As well as the control of body openings and passages. And finally, producing around 85% of our body heat, which is vital for the metabolism (Carey Carpenter, 2007). Classification There are three histological types of muscle—cardiac, smooth and skeletal—which differ in appearance, physiology, and function. The cardiac muscle is essentially limited to the heart, though it extends slightly into the nearby blood vessels. It is involuntary and striated because of the regular arrangement of their actin and myosin filaments. Its cells are much shorter, so they are commonly called myocytes, and are mononuclated (Saladin, 2003). The myocytes assemble branches of adjoining cells and form a network by attaching to each other in attachment points called intercalated discs that provide strong mechanical adhesions between adjacent cells. Smooth muscle lacks striations and is involuntary. Smooth muscle cells are usually long and spindle-shaped, and each fusiform cell has a single and centered nucleus (Purves et al., 2004). Small amounts of smooth muscle are found in the iris of the eye and in the skin, but most of it, called visceral muscle, forms layers in the walls of the digestive, respiratory, and urinary tracts, blood vessels, the uterus, and other viscersa (Alberts et al., 2008). The skeletal muscle type is of special interest of this thesis and will be further studied in the following sections. Skeletal muscle Skeletal muscles are, as the name implies, are bound to the skeleton by means of tendons, which means that they are volitional. It is composed of both muscular tissue and connective. A skeletal muscle cell (muscle fiber) is about 10 to 100m in diameter and 30 cm long. It is surrounded by a sparse layer of areolar connective tissue called the endomysium, which allows room for blood capillaries and nerve fibers to reach each muscle fiber. Muscle fibers are grouped in bundles called fascicles, which are visible to the naked eye as parallel strands. Each fascicle is separated from neighboring ones by a connective tissue sheath called the perimysium, usually somewhat thicker than the endomysium. The muscle as a whole is surrounded by still another connective tissue layer, the epimysium. The epimysium grades imperceptibly into connective tissue sheets called fasciae, deep fasciae between adjacent muscles and a superficial fascia (hypodermis) between the muscles and skin. It is described as striated and voluntary (Saladin, 2003). Structure The skeletal muscle tissue consists of long and cylindrical cells called muscle fibers, which are actually huge single cells that form during development by the fusion of many separate cells, called myoblasts. Each cell contains multiple nuclei adjacent to the plasma membrane, and they are about 10 to 100m in diameter and 30 cm long. The bulk of the cytoplasm inside is made up of myofibrils, which is the name given to the basic contractile elements of the muscle cell. Within each myofibril are thin actin filaments and thick specific muscle isoforms of myosin II filaments (Alberts et al., 2008). Myosin filaments are bundles of molecules with globular heads and polypeptide tails. Actin filaments consist of two chains of actin monomers twisted together. They are wrapped by chains of the polypeptide tropomyosin and studded at intervals with another protein, troponin. In most regions of the myofibril, each thick myosin filament is surrounded by six thin actin filaments, and conversely, each thin actin filament sits within a triangle of three thick myosin filaments. The myofibril consists of repeating units, called sarcomeres, which are the units of contraction, built up of approximately 2.2 microns in length. Each sarcomere is made of overlapping filaments of actin and myosin, which create a distinct band pattern. As the muscle contracts, the sarcomeres shorten, and the appearance of the band pattern changes. Each sarcomere is bounded by Z-lines, which are structures that anchor the thin actin filaments. Centered in the sarcomere is the A-band, which contains all the myosin filaments. The H-zone and the I-band, are regions where actin and myosin filaments do not overlap in the relaxed muscle. The dark stripe within the H-zone is called the M-band; it contains proteins that help hold the myosin filaments in their regular arrangement. The bundles of myosin filaments are held in a centered position within the sarcomere by a protein called titin. Cardiac muscle and smooth muscle also contain sarcomeres, although the organization is not as regular as that in skeletal muscle (Alberts et al., 2008; Purves et al., 2004.). The plasma membrane, called the sarcolemma has tunnel-like infoldings called transverse (T) tubules that penetrate through the fiber and emerge on the other side. The function of a T tubule is to carry an electrical current from the surface of the cell to the interior when the cell is stimulated. Most other organelles of the cell, such as mitochondria and smooth endoplasmic reticulum (ER), are located between adjacent myofibrils. The sarcoplasm also contains an abundance of glycogen, which provides stored energy for the muscle to use during exercise, and a red pigment called myoglobin, which binds oxygen until it is needed for muscular activity. The smooth ER of a muscle fiber is called sarcoplasmic reticulum (SR). It forms a network around each myofibril, and alongside the T tubules it exhibits dilated sacs called terminal cisternae. The SR is a reservoir for calcium ions; it has gated channels in its membrane that can release a flood of calcium into the cytosol, where the calcium a ctivates the muscle contraction process (Saladin, 2003). Muscle contraction For contraction to occur, an action potentials spreads from the end plate and when it reaches the T tubules, it continues down them into the sarcoplasm. Action potentials open voltage-regulated ion gates in the T tubules. These are physically linked to calcium channels in the terminal cisternae of the sarcoplasmic reticulum (SR), so gates in the SR open as well and calcium ions diffuse out of the SR, down their concentration gradient and into the cytosol. The calcium ions bind to the troponin of the thin filaments. The troponin-tropomyosin complex changes shape and shifts to a new position. This exposes the active sites on the actin filaments and makes them available for binding to myosin heads; the myosin heads must have an ATP molecule bound to it to initiate the contraction process. Myosin ATPase, an enzyme in the head, hydrolyzes this ATP. The energy released by this process activates the head, which â€Å"cocks† into an extended, high-energy position. The head temporarily keeps the ADP and phosphate group bound to it. The cocked myosin binds to an active site on the thin filament. Myosin releases the ADP and phosphate and flexes into a bent, low-energy position, tugging the thin filament along with it. This is called the power stroke. The head remains bound to actin until it binds a new ATP. Upon binding more ATP, myosin releases the actin. It is now prepared to repeat the whole process—it will hydrolyze the ATP, recock (the recovery stroke), attach to a new active site farther down the  thin filament, and produce another power stroke (Saladin, 2003). Classes of muscle fibers Not all muscle fibers are metabolically alike or adapted to perform the same task. Some respond slowly but are relatively resistant to fatigue, while others respond more quickly but also fatigue quickly. Indeed, skeletal muscles can be divided into fast and slow twitch fibers and its myosin heavy chain (MHC) isoform expression. Type I (MHC-I): Also called slow oxidative (SO) or slow-twitch. These fibers have relatively abundant mitochondria, myoglobin, and blood capillaries, and therefore a relatively deep red color. They are well adapted to aerobic respiration, which does not generate lactic acid. Thus, these fibers do not fatigue easily. However, in response to a single stimulus, they exhibit a relatively long twitch, lasting about 100 milliseconds (msec). Type II (MHC-II): Also called fast glycolytic (FG) or fast-twitch. They are well adapted for quick responses but not for fatigue resistance. They are rich in enzymes of the phosphagen and glycogen–lactic acid systems. Their sarcoplasmic reticulum releases and reabsorbs Ca2 quickly, which partially accounts for their quick, forceful contractions. They are relatively pale (white fibers). These fibers produce twitches as short as 7.5 msec, but because of the lactic acid they generate, they fatigue more easily than SO fibers. Some authorities recognize two subtypes of FG fibers called types MHC-IIA and MHC-IIB. Type IIB is the common type just described, while IIA, or intermediate fibers, combine fast-twitch responses with aerobic fatigue-resistant metabolism. Type IIA fibers, however, are relatively rare except in some endurance-trained athletes (Saladin, 2003). Notably, human skeletal muscle does not contain MHCIIb (Spangenburg and Booth, 2003; Schiaffino and Reggiani, 1994; Smerdu et al., 1994). In addition, ‘‘hybrid’’ fibers containing two MHC isoforms (i.e., type I/IIA, IIAX, IIXB) can also be present in muscle (Schiaffino and Reggiani, 1994; Staron and Pette, 1993). The fiber types can be differentiated histologically by using stains for certain mitochondrial enzymes and other cellular components, like using immunohistochemical procedures with antibodies against the specific MHC isoforms (Schiaffino et al., 1989; Lucas et al., 2000). All muscle fibers of one motor unit belong to the same physiological type. Nearly all muscles are composed of both SO and FG fibers, but the proportions of these fiber types differ from one muscle to another. Muscle myogenesis Vertebrate skeletal myogenesis proceeds through three stages: determination of the muscle progenitor cells, called myoblasts; proliferation and in some cases migration of myoblasts; and their terminal differentiation into mature muscle by fusing to form multinucleated myotubes (Buckingham et al., 2003; Shi and Garry, 2006). Muscle development Muscle tissuesare derived from themesodermallayer of embryonicgerm cellsin a process known asmyogenesis. All muscles are derived fromparaxial mesoderm [8].The paraxial mesoderm is divided along the embryos length intosomites, corresponding to thesegmentationof the body.Muscle cells come from two cell lineages in the myotome somite, the epimere and hypomere, which formepaxialandhypaxialmuscles, respectively. Most muscles are hypaxial. During development,myoblasts either remain in the somite to form muscles associated with the vertebral column or migrate out into the body to form all other muscles. Myoblast migration is preceded by the formation ofconnective tissueframeworks, usually formed from the somaticlateral plate mesoderm.Myoblasts follow chemical signals to the appropriate locations, where they fuse into elongate skeletal muscle cells (Sweeney, 1997). Muscle differentiation Muscle fibersform from the fusion ofmyoblastsinto multi-nucleated fibers calledmyotubes. In the early development of an embryothese myoblasts will proliferate if enoughfibroblast growth factor(FGF) is present, without differentiating. When these factors are depleted, the myoblasts cease division and secretefibronectinonto theirextracellular matrix and bind to it through _5ÃŽ ²1 integrin, their major fibronectin receptor (Menko and Boettiger 1987; Boettiger et al. 1995). The second stage involves the alignment of the myoblasts together into chains and subsequently into myotubes. This step is mediated by cell membrane glycoproteins, including several cadherins and CAMs (Knudsen 1985: Knudsen et al. 1990). Recognition and alignment between cells takes place only if the two cells are myoblasts. However, identity of the species is not critical (Yaffe and Feldman, 1965). The third stage is the actual cell fusion itself. In this stage,calciumions are critical for development (Shainberg et al. 1969; David et al. 1981). Fusion is mediated by a set of metalloproteinasescalledmeltrins (e.g., c-Met).Myocyte enhancer factors(MEFs) promote myogenesis.Serum response factor(SRF) plays a central role during myogenesis, being required for the expression of striated alpha-actin genes (Wei et al., 1998).Expression of skeletalalpha-actinis also regulated by theandrogen receptor; steroids can thereby regulate myogenesis (Vlahopoulos et al., 2005). The specific extracellular signals that induce determination of each group of myoblasts are expressed only transiently. These signals trigger production of intracellular factors that maintain the myogenic program after the inducing signals are gone. We discuss the identification and functions of these myogenic proteins, and their interactions, in the next several sections. Muscle-specific transcription factors Pax family Satellite cells and proliferating myoblasts is characterized by the expression of Pax-genes, more specifically Pax7 and Pax3, which are transcription factors that regulate proliferation. Back to the developmental stage, in the lateral portion of the somite, which forms the hypaxial muscles, factors from the surrounding environment induce the Pax3 transcription factor. In the absence of other inhibitory transcription, Pax3 then activates the genes encoding two muscle-specific transcription factors, Myf5 and MyoD. In the medial region of the somite, which forms the epaxial muscles, MyoD is induced through a slightly different pathway[1]. Pax7 residing satellite cells proliferating stage and Pax7 knockout mice completely lack satellite cells (Seale et al., 2000). Cells expressing Pax7 is believed to be important for the regeneration of myoblasts. Also the expression of Pax3 has negative effect on the differentiation and it has been shown that this transcription factor is down-regulated in muscle by ubiquitination and proteasomal degradation before differentiation can proceed (Boutet et al., 2007). Pax genes have been shown to regulate the proliferation and survival even of certain cancers such as melanoma (Muratovska et al., 2003). Pax transcription factors are downregulated upon further differentiation and other proteins predominate. Meanwhile Pax3 _____, Pax7 appears only in muscle stem cells (___). MyoD family Muscle cells come from two cell lineages in the somite. In both instances, paracrine factors instruct the myotome cells to become muscles by inducing them to synthesize the MyoD proteins (Maroto et al. 1997; Tajbakhsh et al. 1997). Or also called the myogenic bHLH (basic helix-loop-helix) proteins. The proteins of this family all bind to similar sites on the DNA and activate muscle-specific genes (e.g. the muscle-specific creatine phosphokinase gene by binding to the DNA immediately upstream from it, or the chicken muscle acetylcholine receptor) (Lassar et al. 1989; Piette et al. 1990). MyoD and Myf5 belong to this family and are particularly important for muscle differentiation [2]. Their important role during differentiation is supported by the MyoD-/-/Myf-5-/- mice lacking fully developed skeletal muscle (Rudnicki et al., 1993). Myf-5 promotes myoblasts’ proliferation and is required for the cells to initiate differentiation (Ustanina et al., 2007). Absence of MyoD inhibits differentiation in cell culture and the protein is therefore considered to be a positive regulator of the process (Sabourin et al., 1999). While Pax3 is found in several other cell types, the myogenic bHLH proteins are specific for muscle cells. Any cell making a myogenic bHLH transcription factor such as MyoD or Myf5 is committed to becoming a muscle cell. Myogenic regulatory factors (proper name?) Later than the MyoD proteins expression during differentiation, the myogenin and the myogenic regulatory factor 4 (MRF4) are present. Mice with deleted myogenin in developing myoblasts can start the differentiation process but they cannot move and die soon after birth (Hasty et al., 1993). Among other things, this suggests that myogenin is required at a later stage of the process. Similarly, MRF4 is important for the growth of muscle tissue (Rhodes and Konieczny, 1989). It is noted that the MEF2 family of transcription factors also regulate differentiation (Olson et al., 1995), but their functions are not described in this context. In summary, Pax transcription factors help to sustain it from the stem cell stage of satellite cells, MyoD and Myf-5 act as myogenic determinants in the myoblast’s diet, and myogenin and MRF4 are known as regulators of the later differentiation and muscle fiber formation (Pallari, 2011). Other factors Although some factors that induce differentiation remain unknown, some growth factors and signaling molecules have been shown to regulate the process. Notch signaling is important in animal embryonic development, in that it participates in the cell fate determination (Alberts et al., 2008). Notch has a dual role of myoblasts in that the protein has an inhibitory effect on myoblasts differentiation (Shawber et al., 1996) and simultaneously stimulates their proliferation (Conboy and Rando, 2002). The chemoattractant SDF-1 also has an inhibitory effect on myoblasts differentiation and stimulates their proliferation by activation of the PKCÃŽ ¶ (Ãâ€"demiÃ…Å ¸ et al., 2007). Moreover, differentiation requires the expression and activity of cyclindependent kinase (Cdk) inhibitors, such as p21 and p27, critical for the withdrawal of myoblasts from the cell cycle (Kitzmann and Fernandez, 2001). To fully understand the factors that regulate, activate and inhibit satellite cells and their differentiation requires even much research (Kuang and Rudnicki, 2007; Shi and Garry, 2006.). [1] developmental biology Scott gilbert [2] developmental biology Scott gilbert

Tuesday, August 20, 2019

Rhode Island Nightclub Fire Incident Essay -- essays research papers

The nightclub, is an aged small wood structure in Rhode Island. The club is reported to have a capacity of 182 people. On February 20th 2003, more then 400 fans packed into the small club to see a band. Although there are discrepancies between reports of how many people were in attendance, it is obvious that the number is well over twice the club's capacity. During the performance, as part of the act, pyrotechnics were deployed. The pyrotechnics were gerbs. Gerbs are cylindrical devices that are designed to make a spray of 15-foot plumes of sparks for 15 seconds. Gerbs are befitting for use indoors, as long as the appropriate precautions are taken. The pyrotechnics ignited a polyurethane (egg crate foam) material that is used for packing and product display--but not for "sound proofing," as it was used lining the stage. Considering that this foam is not intended for use as a sound treatment in buildings, it was not treated with fire retardants. Due to the size and age of the building (built before 1976), safety regulations said that the nightclub did not have to have a sprinkler system, and it thus did not have one. The fire originating on the stage quickly filled the club with toxic smoke from the burning polyurethane and other building materials. In the shear moment of panic, the people caused a scene of chaotic proportions: stampeding towards the only exit they knew--the way they got in. Over 400 people all trying to get out one door at the same time caused a massive pileup trapping the majority of people inside. Just prior to the fire department arriving on scene the super heated gases trapped in the building ignited causing what is called a â€Å"flashover." Temperatures exceeding 932 to 1112 degrees Fahrenheit inst... ... these pyrotechnics in this situation would have been revealed before the show. Lastly, the enforcement of the capacity—the number of people allowed in club would have dramatically decreased the number of fatalities and injuries in this incident. In conclusion, it is clear that situations like this could easily be prevented with a few vitals steps. The first step in the line of prevention is restriction of flammable materials in nightclubs and other buildings, especially in enclosed spaces. Second is the installation of fire prevention systems—fire extinguishers, sprinkler systems and fire alarms with early notification to the local fire authorities. Also, the prevention of using dangerous pyrotechnics in enclosed spaces is imperative. Finally, the need for sufficient exits is vital to the safety of the people in any building, especially a crowed nightclub.

Monday, August 19, 2019

MoveOn and the New Front of Grassroots Activism :: Essays Papers

MoveOn and the New Front of Grassroots Activism This election year, a new style of grassroots activism has risen up to a very strong position. When the two owners of computer software company Berkeley Systems (made famous for the After Dark flying toaster screensaver and the popular game You Don’t Know Jack) decided to sell their company for $14 million dollars, they were unaware of what their future held. In 1998, during the impeachment of former President Bill Clinton, Wes Boyd and Joan Blades decided to put together a list of names in effort to petition Congress to reprimand Clinton and then â€Å"move on.† When their list grew to more than 300,000 names within one month, they knew they had something big on their hands. Although their efforts concerning the Clinton impeachment failed, they were not about to give up. They went on to protest the 2000 presidential election campaign, raise $2 million to air a television ad called â€Å"Child’s Pay† during the Super Bowl (which was denied by CBS due to its policy against issue advertisements), and then to go up against President George W. Bush concerning the war in Iraq. MoveOn is best known by its website (www.moveon.org), which has drawn millions of visitors since it was established. Though many Republicans and some Democrats protest MoveOn’s so-called â€Å"extremist† advertising, there is no doubt about it: grassroots campaigning had a new face. With MoveOn’s overwhelming success, other smaller activist groups began springing up all over the Internet in effort to catch some of MoveOn’s success. The fact is many of them are doing just that. The Internet is slowly becoming the largest political campaign tool available. And with the ease of connecting with millions of people with the simple click of a button, the voices grassroots activists is more powerful than ever before. MoveOn’s next mission is by way of mass telephone calls, hoping to reach 800,000 people a day. MoveOn plans on beginning these calls in late October. How is this possible? MoveOn has created a way in which volunteers (both old and new) dial a toll-free number, punch in their special identification number, hear a brief message concerning the strategy of their calls for that day, and then be instantly connected to an American somewhere.

Sunday, August 18, 2019

Theatre In Changing Society :: essays research papers

Theatre will always survive in our changing society. It provides us with a mirror of the society within which we live, and where conflicts we experience are acted out on stage before us. It provides us with characters with which we identify with. The audience observes the emotions and actions as they happen and share the experience with the characters in real time. The survival of theatre lies in the very nature of humankind: its inner voyeuristic drive. The desire to watch other people dealing with their conflicts and fates challenges as well as reinforces values and the morality of society. The theatre provides an exciting opportunity to watch stories and situations as if they were real life, showing us the truth of our nature. For as long as humankind exists, theatre will always take on an important function within its cultures. Through theatre, a culture expresses itself, reflects its society, and displays its individuality. It invites people to experience other cultures. Nevertheless, the question at hand is whether theatre will have a role in the society of the future, where cinema, digital television, and computers will continue to expand and grow. The answer to this question is yes. Heading into the 21st century, theatre will only be a fraction in a solid media industry. However, despite all the excitement technology brings with it, they will never replace theatre because it has something that can not be recreated or offered anywhere else. The cinema and its larger than life world appeals as an affordable alternative. Digital television provides digital interaction between the viewer and the producer. Theatre on the other hand, and its contents may take on a larger dimension, but we receive it directly in flesh and blood – one to one. The magical atmosphere between an actor and spectator who are constantly aware of each other and the theatre’s level of engagement is fundamentally more human and far more intimate.

Saturday, August 17, 2019

Kes the Play

kes In this assignment I am writing about the play called†kes†how Barry Hines the author of Kes brought his characters to life. He has gone into great detail and time to produce this play by trying to bring his characters to reality by their language , the surroundings of that area and the clothing they wear. The area where this scene is set is in a rough, unpleasant place, Barnsley. Although Barnsley is local to us, it is an industrial working class area were poor unwealthy people go to work and try to make end meet to feed their families. All these characters show how they act as normal on an ordinary day, because Barry Hines needed to get across the description that effect his characters in the play. Billy did not have a good relationship between his family his mom and brother. His mom does not care for Billy, all she wants to do is go to parities and knockabout with men, this shows that her children don’t come first in her life. Billy clothes are dirty and appalling with wholes and stains in them because he doesn’t wash his clothes. In the morning when he wakes up his mom doesn’t leave tea in the pot for him and tells him to go to the shop for her to buy cigs, before he goes to school, so Billy will be late, Billy runs out the house and goes to school after having an argument with his mom to go to the shop for cigs. His mom doesn’t have any money for him for hi school dinner because she spent it the night before or she needs it for the night ahead. Billys brother Jud steals his snap for school and takes his bike so Billy’s got nothing for school. Jud went out one night and got really drunk when he came home, Jud woke Billy up to undress him because he was too drunk to do it himself, it is the only way Billy can get his own back by slapping and shouting at him â€Å"you drunken sow og pig bastard. Billys school life is not much better than his home life; his school is run down, horrible and dirty. He thinks the whole world is against him and does get along with other kids in school he doesn’t knock about with any mate’s accept his kestrel bird. Barry Hines the other of Kes describes a bewildering scene into which Billy fits appropriately when he is fighting over a schoolmate over his brother â€Å"Im not frightened of him that would be if he were here I bet I know somebody who could fight him. Soon the fight broke out in the playground everyone gathered round. There is one teacher in the school that takes and interest in Billy due to the hawk. He helped Billy against McDowel so Billy would not get into trouble. The teacher Mr Farthering finds out about Billy’s hawk and asked if he could see the bird. The kestrel is the only pleasure Billy gets in his life, he found it in the formers land in the forest and asked if he could have it, ever since he has owned Kes (name of the bird) he’s been training it, he was so interested in this bird he went to the library to find a book on kestrel but he was not allowed to take it out because he was not a member so he stole it, because Billy was not wealthy his brother and him had to share a bed together. Billy has a paper round, when he goes to collect his papers he steals chocolates and drinks he does this because he is hungry and he probably doesn’t get enough food at home. Billy does his papers in a bad area, the owner of the newsagent Mr Potter said Billys brother Jud gave Billy ? 10 to go and bet on a hoarse, so he went down prepared to bet for Jud as he was down there, Billy spoke to one of Jud’s mates and said it wasn’t worth betting on that hoarse, well Billy did not need to be told twice so he used the money to buy food for him and his bird. As soon as Jud found out his hoarse won and there was no bet on it he went looking for Billy, but Billy hid every time he saw his brother, so Jud stopped looking and went to find Billys only friend in the world and killed his hawk. As soon as Billy found his bird he ran and buried it in the field and went to bed.

Friday, August 16, 2019

Acute Ankle Inversion Sprain Health And Social Care Essay

Ankle is a complex articulation which is categorized as a flexible joint articulation. It is one of the of import constituent for ambulation in worlds. Ankle sprains are one of the commonest hurts in sports. It accounts for 20 % of all athleticss hurts ( Bergfeld J ; 2004 ) .In India, incidence rate of mortise joint sprain histories for 0.31 % of the population and the opportunities of re-injury is seen every bit high as 78-80 % despite the continued research in this field ( Statistics for ankle sprain ; 2003 ) . The pathomechanics for ankle inversion hurt is inversion and plantar flexure of the ankle articulation. There is loss of dorsiflexion and inversion scope of gesture which is attributed to trouble and swelling ( Denegar CR et Al ; 2002 ) , ( Collins et Al ; 2004 ) .According to Denegar C et Al ( 2002 ) the loss of dorsiflexion scope of gesture is due to limitation of posterior talar semivowel. This suggests that in an acute mortise joint inversion sprain the loss of dorsiflexion scope of gesture could be due to mechanical disfunction in talocrural articulation. The conventional intervention for acute mortise joint sprain is RICE ( remainder, ice, compaction, lift ) .The chief purpose of conventional intervention ( RICE ) is chiefly to cut down hurting and redness ( Starkey JA ; 1976 ) , ( Slatyer MA et Al ; 1997 ) . The conventional intervention ( RICE ) with early motion is found to be more effectual for cut downing hurting, swelling and bettering mobility ( Dettori et al ; 1994 ) . Because of the ineffectualness of conventional intervention for handling the positional disfunction caused due to acute ankle inversion hurt the joint becomes more susceptible to injury ( Hertel J et Al, 1999 ) . Manual Therapy focuses on decrease of hurting and rectification of the postural and motion disfunction due to ankle sprain. Harmonizing to Maitland classs of mobilisation class I and II mobilisation is used in acute status and class II mobilisation is seem effectual in cut downing hurting and bettering dorsiflexion scope of motion in acute musculoskeletal conditions. Maitland classs of mobilisation improves the ankle dorsiflexion in acute ankle inversion sprain ( Green et Al ; 2001 ) and reduces pain by transition of nervous tissue ( Vincenzino B et Al ; 1998 ) . Harmonizing to Maitland GD ( 1986 ) , inactive articulation mobilisation improves the scope of motion by soft oscillating motion of the articular surfaces that creates motion of the nomadic sections by a means other than the musculuss.According to Collins et Al ( 2004 ) , Mulligan ‘s mobilisation with motion technique is effectual in cut downing hurting and improves dorsiflexion of ankle articulation. A individual inst ance survey done by O Brien, B.Vincenzino ( 1998 ) showed that Mulligan Mobilization with motion technique on acute mortise joint sprain improved the scope of motion ( dorsiflexion and inversion ) , functional result and reduced the hurting. Harmonizing to pilot survey conducted by John-Mark Chesney, Erin Morris, Mulligan ‘s mobilisation with motion technique and tape had important consequence on temporal and spacial parametric quantities of pace. Immediate lessening in hurting and an early return to map are claimed to be consequence of Mulligan ‘s mobilisation with motion Mulligan 1995 ; Vincenzino Wright 1995 ; Hetherington 1996 ) . However, the deficiency of equal grounds in literature for the effectivity of Mulligan ‘s anterior-to-posterior talar semivowel with motion technique in acute ankle inversion sprain failed to turn out its clinical and statistical significance in research methods. The above literature besides shows deficiency of surveies done to compar e the effects of Maitland and Mulligan mobilisation technique in intervention of acute ankle inversion sprain. Hence, the purpose of the survey is to happen the immediate consequence of Mulligan ‘s anterior-to-posterior talar mobilisation with motion technique in acute ankle inversion sprain with RICE and compare the consequences with that of Maitland anterior-to-posterior talar semivowel mobilisation with RICE for intervention of acute ankle inversion sprain.REVIEW OF LITERATUREAnkle articulation is a complex articulation due to its articular, ligamentous and sinewy anatomy. The anterior talofibular ligament restricts anterior interlingual rendition and internal rotary motion of talus inside the mortice. The conjugate gesture during plantar flexure happens as internal rotary motion and anterior interlingual rendition of scree aided by deltoid ligament. The calcaneofibular ligament restricts inversion of the talocrural and subtalar articulation. The posterior talofibular ligament restricts inversion and internal rotary motion after calcaneofibular ligament and anterior talofibular ligam ent undergo hurt. Harmonizing to Konradsen and Voight ( 2002 ) an inversion torsion was produced on lading a cadaverous leg, when the unloaded pes was positioned in 30 degree inversion, full plantar flexure and 10 degree internal tibial rotary motion. The hit with 20 grade upside-down pes in swing stage follow through forced the pes into full bound of inversion, plantar flexure and internal tibial rotary motion. Harmonizing to Denegar CR et Al ( 2002 ) in normal biomechanics the instantaneous axis of rotary motion of talocrural articulation translates posteriorly during dorsiflexion, but in anterior malaligned scree or with restricted posterior talar semivowel the axis of rotary motion is shifted anteriorly taking to joint disfunction. Harmonizing to Baumhauer JF et Al ( 1995 ) old history of sprain, limited scope of gesture and decreased dorsiflexor and plantar flexor strength ratio, elevated eversion to inversion ratio have been attributed to predisposing to inversion hurt. Harmonizing to Eren OT et Al ( 2003 ) high malleolar index ( posteriorly positioned calf bone ) is attributed to predisposing factor to twist. Average malleolar index was +11.5 grade in topics with ankle sprain and +5.85 degree in normal controls. Green T in 2001 used a Modified Lidcombe Template to mensurate the hurting free dorsiflexion scope of gesture happening in talocrural articulation. The templet consisted of 2 boards joined by an adjustable flexible joint. One board served as a footplate and other was placed under the topic ‘s calf. The adjustable flexible joint served as the axis of rotary motion of templet in perpendicular plane and the board placed under the topic ‘s calf allowed for accommodation in horizontal plane. The measuring was standardized by mensurating both force applied and the angle of dorsiflexion at which the topic foremost experienced the hurting ( Matyas T, Bach T ; 1985 ) . The force applied was standardized throughout the trail by spring balance and the way of force was standardized by spirit degree attached to the spring. The device showed high intrarater and interrater dependability of which 29 % were in exact understanding and 84.5 % were within 2 grades, ICC=0.94. The conventional direction of mortise joint sprain is RICE in acute phase of hurt. The functional intervention processs with early induction of weight bearing as tolerated, early mobilisation, proprioceptive preparation, balance preparation has been advocated to supply early functional rehabilitation to topics. Harmonizing to Bahr R ( 2004 ) and Bruce Beynnon B, ( 2004 ) the direction of sprain dressed ores on inactive and dynamic stableness, deriving normal ankle scope of gesture, optimum strength of peroneal, dorsiflexors, plantar flexors, and invertor musculuss of mortise joint and retraining ankle scheme. Harmonizing to Kerkhoffs et Al ( 2002 ) functional intervention is superior to immobilisation and surgical intercession in countries of hurting on activity, quality of public presentation on return to sport/work, objectives instability on x-ray positions and patient satisfaction. Manual therapy in ankle inversion sprain Maitland ‘s Mobilization Green et Al ( 2001 ) conducted a randomized controlled test of inactive accoutrement joint mobilisation on acute ankle inversion sprain. The survey included 38 topics with acute ankle inversion sprain ( & lt ; 72hours ) and were indiscriminately assigned to command group ( RICE ) and experimental group ( anterior-to-posterior mobilisation and RICE ) .Treatment was given every 2days for maximal 2weeks.The intervention technique used in this survey was Maitland ‘s class 3 front tooth to posterior talar semivowel of scree. Consequences showed that dorsiflexion improved earlier in experimental group as compared to the control group. Elizabeth L et Al ( 2008 ) conducted a survey in which 10 topics were taken with immobilized mortise joint for at least 14 yearss and presented with at least 5 grade of dorsiflexion shortage compared to contralateral mortise joint. A crossing over design was employed and topics received Maitland ‘s class 3 mobilisation in one group and control intercession ( no intervention ) in other group. Consequences showed that joint mobilisation led to a decrease in hurting and betterments in unpainful dorsiflexion. Mulligan mobilisation with motion technique Collins et Al ( 2004 ) conducted a double-blinded randomized controlled test with a crossing over design attack. In this survey 14 topics with grade 2 mortise joint sprain were taken. The dorsiflexion in weight-bearing and thermic hurting threshold were calculated. All the topics undergo 3 intervention conditions-Mulligan ‘s mobilisation with motion technique for dorsiflexion, placebo group and control group ( no intervention ) .Results showed that the talar anterior-to-posterior semivowel improved the recovery rate in intervention with Mulligan ‘s mobilisation with motion technique. The survey conducted by Collins N was done on topics with sub ague mortise joint sprain. T O'Brien, B.Vincenzino ( 1998 ) conducted a individual instance survey to look into the effects of Mulligan ‘s with motion technique mobilisation for acute sidelong mortise joint sprain. The technique used in this survey was posterior semivowel to distal fibular while patient actively inverted the mortise joint. In the survey 2 topics with acute mortise joint sprain were used to command for natural declaration of mortise joint sprain. Capable I underwent ABAC protocol while capable II BABAC protocol where A was no intervention stage B was intervention stage and C was post intervention return to feature stage. The result steps Modified Kaikkonen test functional result, VAS for hurting and scope of dorsiflexion and inversion were measured pre and station of each intercession session. Consequences showed rapid betterment of scope of gesture ( inversion and dorsiflexion ) and immediate lessening in hurting. Therefore from the above surveies we can deduce that anterior-to-posterior talar semivowel technique in both Maitland and Mulligan mobilisation is effectual in handling ankle inversion sprain than the RICE protocol entirely. The above surveies besides infer that Maitland ‘s classs of mobilisation is significantly effectual in bettering dorsiflexion scope in acute mortise joint sprain. However, Mulligan ‘s mobilisation had shown effectual consequences in handling mortise joint sprain in subacute status. The survey done by T O'Brien, B.Vincenzino ( 1998 ) shows the effectivity of Mulligan ‘s mobilisation with motion technique in bettering dorsiflexion scope of gesture in acute mortise joint sprain but the survey design leads to restriction of generalisation of its findings. However, it does supply the cognition to carry on a random clinical trail in public-service corporation of Mulligan ‘s mobilisation with motion technique in the intervention of acute ankle in version sprain and to compare the consequences with Maitland ‘s classs of mobilisation to happen the best effectual intervention method for bettering the recovery rate in ague mortise joint inversion sprain.IDENTIFICATION OF RESEARCH PROPOSAL QUESTIONDoes Mulligan ‘s anterior-to-posterior talar semivowel is effectual in bettering dorsiflexion in topics with acute ankle inversion sprain than Maitland ‘s anterior-to-posterior talar semivowel mobilisation.ALTERNATE HYPOTHESISMulligan ‘s anterior-to-posterior talar semivowel is effectual than Maitland ‘s classs of mobilisation in bettering dorsiflexion scope of gesture in topics with acute ankle inversion sprain.NULL HYPOTHESISMulligan ‘s anterior-to-posterior talar semivowel is non effectual than Maitland ‘s classs of mobilisation in bettering dorsiflexion scope of gesture in topics with acute ankle inversion sprain.MethodologyDesign An Experimental, Comparative, Randomized Controlled Trail design. The survey will be individual blinded to avoid any possible prejudice. The topics will be allocated to 3 group of interventions-Mulligan ‘s anterior-to-posterior talar semivowel with motion technique with RICE, Maitland ‘s anterior-to-posterior talar semivowel mobilisation with RICE, and 3rd group RICE entirely.Outcome step will mensurate the grade of dorsiflexion pre and station to each session which will be measured by the assessor blinded to the allotment of topics to the groups. Subjects The survey will be conducted by enrolling 90 samples through convenience sampling by giving advertizements and notices to orthopaedic and physiotherapy section in MS Ramaiah Memorial infirmary and the infirmaries nearby its environing countries. The topics recruited will be diagnosed for acute ankle inversion sprain and referred by radiotherapist through X-Ray imagination. To keep the homogeneousness of the groups all the topics will be recruited based on Inclusion and exclusion standards. Inclusion criteria-All topics of age group 20-30years of age, History of ankle inversion hurt with hurting over sidelong facet of mortise joint ( & lt ; 72hours ) of hurt, shortage of at least 5 grades of dorsiflexion, topics are able to partial weight bear on affected mortise joint, hurting, swelling and tenderness over sidelong facet of mortise joint. Exclusion criteria-Subjects holding ankle break, any history of old surgery or sprain on affected leg, any consumption of anti-inflammatory or anti -coagulants post hurt, subjects with vascular diseases.ETHICAL APPROVALThe ethical blessing will be taken from Ethical Board of MS Ramaiah Memorial Hospital along with the permission of other infirmaries near by its milieus. Subjects will be given a transcript of informed consent with the inside informations of the survey and the confidentiality of patient ‘s forces information and information obtained after the survey will be maintained. Subjects can retreat from survey at any given point of clip.VENUE/LOCATION OF THE STUDYThe survey will be conducted in MS Ramaiah Memorial Hospital Physiotherapy Department, Bangalore.A RANDOMIZED CONTROLLED TRAIL STUDYAn experimental randomized controlled trail -single blinded survey will be conducted on 90 topics with acute ankle inversion sprain. The technique of the intercessions will be finalized during the survey and side-effects or any mistake in the intercession will be noted and rectified.RESEARCH METHOD AND EXPERIMENTAL INTERVENTION 90 samples will be recruited by convenience sampling. The samples will be assessed for acute ankle inversion sprain by X-Ray imaging done by the radiotherapist in radiology section of MS Ramaiah Memorial Hospital. The topics will be indiscriminately assigned to 3 groups by chit method. Each group will be assigned 30 topics. The research worker who will carry on the survey is a qualified physical therapist who specializes in manual therapy. After the allotment of the group the experimental group I will have Mulligan ‘s front tooth to posterior talar semivowel along with active dorsiflexion of mortise joint which will be followed by RICE application. The mobilisation will be performed in weight bearing in which the healer applies a postero-anterior force to distal leg through a intervention belt while stabilising the pes and scree ( Mulligan ; 1999 ) .The experimental group II will have Maitland ‘s anterior-to-posterior talar semivowel ( Grade II ) followed by RICE application. The mobilisation will be performed with capable lying supine and the mortise joint will be positioned over the border of pedestal with proximal manus of healer stabilising the distal shinbone and calf bone while the distal manus will mobilise the scree with posteriorly directed osc illation ( Maitland ; 1977 ) .Group III will have RICE intervention for upper limit of 2 hebdomads. Subjects in experimental group I and II will be treated every 2nd twenty-four hours for upper limit of 2 hebdomads. Therefore 6 Sessionss of intervention over 14 yearss will be done. Three sets of 10 repeats will be applied with 1 minute between sets ( Exelby, 1996 ) in both mobilisation technique. Pain experienced during intervention will ensue in immediate surcease of technique and exclusion of the topic from survey.Result MEASURESDorsiflexion scope of gesture will be measured by Modified Lidcombe templet. The templet enabled standardised measuring of dorsiflexion scope of motion. The axis of rotary motion of mortise joint was aligned with adjustable axis of rotary motion of templet. The spring balance attached to the footplate step the force applied in the standardised way. A hydrogoniometer placed on the footplate measures the scope of dorsiflexion in grades. The templet have a hi gh intrarater and interrater dependability of which 29 % were in exact understanding and 84.5 % were within 2 grades, ICC=0.94. Hydrogoniometer have high intraclass coefficients ( 0.84-0.99 ) which revealed high understanding between the raters ( Lex D.De Jong et Al ; 2007 )RESULTS AND DATA ANALYSISThe dorsiflexion scope of motion measured will be in grades which represent a parametric information. The information collected pre and station of each 6 session in group I and group II will be analyzed by related t trial ( i.e. within the group ) and unrelated T trial will be done to compare between the group I and group II for dependent variable. One manner ANOVA will be used for analysis of informations from all the 3 groups along with Scheffe trial to happen the most effectual group for intervention of acute ankle inversion sprain. The degree of significance will be set at 0.5 ; the chance will be calculated based on the T value with grade of freedom tabular array. The assurance inter val will be kept to 95 % .ANNEXUREPROJECT TIMELINEThe overall estimated clip required for the completion of the survey is 8months i.e. 1 month for ethical clearance, 4 months for the randomized controlled trail, informations aggregation and information analysis, 1 month for composing up and showing consequences and 2 months for printing consequences. Undertakings 1 2 3 4 5 6 7 8 Ethical clearance+Randomized controlled trail & A ; amend informations aggregation tools+Data aggregation+++Datas analysis++Writing up & A ; showing consequences+Printing consequences++BudgetThe overall appraisal of the budget is Rs30, 000 which includes X-RAY imaging – Rs20, 000 ( 90 topics ) Modified Lidcombe Template and hydrogoniometer – Rs5000 Stationary – Rs1000 Transportation system and refreshments – Rs4000INFORMED CONSENTIntroduction This is an informed consent given to a topic who wishes to take part in research survey. Please red the informed consent carefully or you can inquire anyone of your relation who you trust can read this informed consent for you in your linguistic communication by interpreting it. Please experience free to inquire any inquiries you have about this informed consent or research survey in your head. Please sign the consent signifier merely after you have no uncertainties about the research survey or consent signifier. Make non subscribe the consent signifier under any sort of force per unit area. Title of Research Project Immediate effects of Mulligan ‘s anterior-to-posterior talar semivowel with motion technique versus Maitland ‘s anterior-to-posterior talar semivowel for hurting free dorsiflexion in acute ankle inversion sprain. Research worker SUMIT KIMOTHI M. Sc in Clinical Physiotherapy. Purpose Of Study Acute mortise joint sprain has high per centum re-injury. Mulligan ‘s mobilisation with motion technique helps in bettering dorsiflexion scope of gesture by rectification of positional disfunction of articulation. This survey is to happen the consequence of Mulligan ‘s mobilisation with motion technique and compare it with effects of Maitland ‘s classs of mobilisation in intervention of acute ankle inversion sprain. Description of Study After being diagnosed with acute ankle inversion sprain you will be sent to the physical therapy section in physical therapy section. The research worker will explicate you about the intervention technique and the survey and an informed consent will be given to you based on your determination your engagement will be decided. If you wish to take part a intervention technique selected for the several group in which you will allocated will be performed on you and the appraisal will be taken earlier and after the intervention session. The continuance of intervention is 2 hebdomads and if there is any alterations, you will be informed prior. Possible Hazards or Complication The intervention technique itself has no side-effects or complication and it will be performed by a qualified physical therapist in Manual Therapy. Treatment Alternative If the therapy is non effectual to you, you will be provided with an alternate intervention with free of cost. Fiscal Deductions All the disbursals sing the research work including the probe, transit, nutrient disbursals and intervention will be free of cost. Potential Benefits The survey may be good to society and persons of similar status. You can profit by bettering you status with aid of this intervention. Engagement Engagement in this research survey is voluntary. If the participant wants to retreat he/she can retreat at any given point of clip.CONSENT FORMI have read the predating information, or it has been read to me. I have had the chance to inquire inquiries about it and any inquiries that I have asked have been answered to my satisfaction. I consent voluntarily to take part as a participant in this research and understand that I have the right to retreat from the research at any clip without in any manner impacting my medical attention. Name of the participant _____________________ Signature of participant _____________________ Date: _____________________ Day/month/year ___________________If nonreaderA literate informant must subscribe ( if possible, this individual should be selected by the participant and should hold no connexion to the research squad ) . I have witnessed the accurate reading of the consent signifier to the possible participant, and the person has had the chance to inquire inquiries. I confirm that the person has given consent freely. Name of informant ___________________ AND Thumb print of participant Signature of informant ___________________ Date: ______________ Day/month/year ______________ I have accurately read or witnessed the accurate reading of the consent signifier to the possible participant, and the person has had the chance to inquire inquiries. I confirm that the person has given consent freely. Print Name of Researcher _________________ Signature of Researcher ___________________ Date __________ Day/month/year ____________ A transcript of this Informed Consent Form has been provided to participant ____________ ( initialed by the researcher/assistant ) For more information contact: Sumit Kimothi M. Sc in clinical physical therapy, MS Ramaiah Memorial Hospital, Bangalore. 9916261101ASSESSMENT CHARTName: Age: Sexual activity: Site of Disorder: Mode of Treatment: Measurement: Parameters Before Treatment After Treatment Dorsiflexion scope of gesture Signature of Clinician: Signature of Chief Physiotherapist: